The Beckmann rearrangement is a significant reaction in organic chemistry that transforms ketoximes into amides, particularly lactams, which are valuable in the synthesis of various ...

A considerable and unanticipated plasticity of the human genome, manifested as inter-individual copy number variation, has been discovered. These structural changes constitute a major source of ...

It is likely that NHEJ and MMEJ contribute to some chromosomal rearrangements by joining non-homologous sequences. This might occur during repair of two-ended DSBs (such as endonuclease-induced ...

SRC1 was the first cloned steroid receptor co-activator that interacts with steroid hormone receptors to promote transcriptional activation in a hormone-dependent manner. The p160 SRC family ...

Alternatively, concordance is often the result of recurrent rearrangements driven by predisposing genomic sequences, such as nearby segmental duplications, or a balanced variant such as an inversion.

Key Laboratory of Tropical Marine Bio-resources and Ecology, Guangdong Key Laboratory of Marine Materia Medica, Innovation Academy of South China Sea Ecology and Environmental Engineering, South China ...

With the advancements of molecular genetics and the identification of mutations in the genes encoding the cardiac ryanodine receptor and cardiac calsequestrin 2 in patients with CPVT, the central role ...

Cellular aging is a multifactorial and intricately regulated physiological process with profound implications. The interaction between cellular senescence and cancer is complex and multifaceted, ...

The volumes of a cell [cell volume (CV)] and its organelles are adjusted by osmoregulatory processes. During pinocytosis, extracellular fluid volume equivalent to its CV is incorporated within an hour ...

Epilepsy is now considered a network disease that affects the brain across multiple levels of spatial and temporal scales. The paradigm shift from an epileptic focus—a discrete cortical area from ...