Leaving the Fc region alone could help the antibodies inhibit regulatory T cells that can reduce antitumor activity, but some argue it may also do away with some cytotoxic T cell activity as well.

B Cells are a type of lymphocyte whose primary purpose is to generate highly specific antibodies in response to a foreign antigen. The B cell receptor (BCR) signaling pathway regulates B cell ...

A team of scientists has uncovered the remarkable potential of a human antibody, mAb 3A6, in fighting Ebola virus infections.

Discover how early functional screening at the single-cell level transforms therapeutic development of your antibodies.

Addressing these risks is crucial to mitigating the rising cancer burden in the region. Key Market Challenge: Limited Tumor Types Limited tumor types targeted by Antibody Drug Conjugates (ADCs ...

Addressing these risks is crucial to mitigating the rising cancer burden in the region. Key Market Challenge: Limited Tumor Types Limited tumor types targeted by Antibody Drug Conjugates (ADCs) pose a ...

To address this problem, antibody engineers introduced a serine-to-proline substitution that made the middle hinge region more like that found in IgG1 (ref. 7). This not only gave a more ...

The study by Li et al. provides fundamental findings supported by convincing evidence that they defined cellular reprogramming of androgen receptor in neuroendocrine prostate cancer (NEPC). The ...

PCI Pharma Services (“PCI”) – a leading global contract development and manufacturing organization (CDMO) focused on ...

MANKATO — A regional traffic-sign replacement project begins Monday, according to the Minnesota Department of Transportation. Traffic signs that are at the end of their service lives will be ...