Research that focused on blocking the renin-angiotensin system (RAS ... the conversion of AT-I to AT-II, ACE inhibitors block the degradation of bradykinin via kininase II, which has enzymatic ...

In contrast, ARBs would be expected to inhibit the biologic effects of angiotensin II more completely than ACE inhibitors, since they block the pathway more distally at the level of the receptor ...

Excess of the inflammatory molecule bradykinin ... angiotensin system (RAS), involved in blood pressure regulation and fluid balance, was askew. Jacobson followed this abnormal RAS in the lung fluid ...

Drugs in this class also decrease ACE-dependent degradation of substance P and bradykinin ... found between CRPS and the use of angiotensin-II-receptor blockers. These antihypertensive drugs ...