Consistent with previously published work suggesting that S6K is the principal downstream signal affected ... 6 and also the trial of an AKT inhibitor in which a patient with metastatic pancreatic ...

Objective The authors explored differentially expressed circRNAs in Acute Ischemic Stroke (AIS) and revealed the role and potential downstream molecular mechanisms of circLOC375190. Methods ...

The classic roles of NOTCH, PI3K/AKT, MYC, PPAR, and interferon regulatory factors (IRFs) in macrophage polarization have been further established while prominent roles for metabolism, microRNAs ...

Glioblastoma is the most common primary malignant tumor of the central nervous system, which has the characteristics of strong invasion, frequent recurrence, and rapid progression. These ...

The study conducted by Fang et al. offers significant and fundamental insights, notably enhancing our understanding of angiogenesis. While some of the claims are supported by convincing experimental ...

pS6 positive cells encompassed also T, B and dendritic cells (DCs) and AKT activation (figure 1I). These data suggest that PI3Kδ is engaged in several cell types within pSS inflammatory infiltrates ...

Objectives Osteoarthritis is associated with cell death and extracellular matrix degradation in articular cartilage. Autophagy is an essential cellular homeostasis mechanism that was found to be ...

PI3K-Akt signalling and ketone body metabolism of tumour cells are associated with CD8+ T cell infiltration in HCC microenvironment. The novel immunophenotypic classification can be recapitulated ...

This month's cover highlights the article Nup358 restricts ER-mitochondria connectivity by modulating mTORC2/Akt/GSK3β signalling by Joseph, Misha Kalarikkal and colleagues. The image shows a human ...

Department of Chemistry, Georgia State University, Atlanta, Georgia 30302-3965, United States ...