Inflammation-triggering cellular pathway identified as potential new drug target for Alzheimer's disease
A team of researchers from the Keck School of Medicine of USC has unlocked the details of a cellular pathway that triggers ...
eLife6d
Targeting IRE1α improves insulin sensitivity and thermogenesis and suppresses metabolically active adipose tissue macrophages in obesity
The evidence supporting the conclusions is convincing and the work will be of interest to cell biologists and biochemists working in metabolism, insulin resistance, and inflammation. Overnutrition ...
eLife6d
Targeting IRE1α improves insulin sensitivity and thermogenesis and suppresses metabolically active adipose tissue macrophages in obesity
Their findings suggest that pharmacological inhibition of IRE1α could influence key aspects such as adipose tissue inflammation ... be of interest to cell biologists and biochemists working in ...
Frontiers5d
Obesity, Metabolic Syndrome, and Musculoskeletal Disease: Common Inflammatory Pathways Suggest a Central Role for Loss of Muscle Integrity
Inflammation can arise in ... inappropriate temporal recruitment of these cells, which in turn leads to impaired angiogenesis and myocyte formation, while promoting the deposition of fibrotic and ...
Science Daily6d
Obese and healthy
Body weight and body mass index alone are not enough to predict whether someone will develop a metabolic disease. A new atlas of cells in fat tissue could help to explain why some overweight people ...
Medscape2d
Adipose Tissue Inflammation and Increased Ceramide Content Characterize Subjects With High Liver Fat Content Independent of Obesity
We hypothesized if adipose tissue inflammation is important for fat accumulation in the liver, then adipose tissue should be inflamed in obese subjects who have excess fat in the liver compared ...
Science Daily5d
Major driver of inflammatory pathology in autoimmune and chronic inflammatory diseases
Researchers discovered a previously unknown mechanism that may drive tissue damage and a new target for drug discovery.
Medscape2d
Adipose Tissue Inflammation and Increased Ceramide Content Characterize Subjects With High Liver Fat Content Independent of Obesity
Cite this: Adipose Tissue Inflammation and Increased Ceramide Content Characterize Subjects With High Liver Fat Content Independent of Obesity - Medscape - Jul 09, 2007. Fasting serum insulin (mU ...
News Medical on MSN3d
Decoding fat tissue
Research from the University of Delaware uncovered key differences in gene expression linked to inflammation, metabolism and cardioprotection. These findings could help inform the development of ...