De novo antibody design has been one of the major challenges in AI-based drug discovery, requiring atomic-level precision to ...

Binders with varying binding strengths were identified for six targets, including PD-L1, HER2, EGFR(S468R), ACVR2A/B, FZD7, and ALK7. Notably, the team successfully designed antibodies targeting ...

The identified ligand-receptor pairs, such as INHBA-ACVR1B and INHBA-ACVR2A/B, further emphasize the functional cross-talk between epithelial and myeloid cells, potentially affecting cellular ...

Comparison of PREMM5 and PREMMplus Risk Assessment Models to Identify Lynch Syndrome Chondrosarcomas are rare cancers of cartilage with limited systemic therapy options. To identify potential ...

Impact of Insurance Status on Survival Outcomes in Patients With Metastatic Renal Cell Carcinoma This retrospective analysis included patients with cancer who had commercial ctDNA tests (K-Track, Gene ...

1 Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, United States 2 Department of Urology, Beth Israel Deaconess Medical Center and Harvard Medical ...