Approval is for use in myelofibrosis patients with moderate to severe anaemia who are JAK-naive or previously treated with ...

That is the predicament of patients with fibrodysplasia ossificans progressiva (FOP) or “Stone Man Syndrome”, a rare musculoskeletal condition where, after birth and progressively through life, ...

Pancreatic ductal adenocarcinoma (PDAC) is the fourth leading cause of cancer-related mortality worldwide. Current treatment modalities are few or ...

The expression of cancer stemness markers, like CD44, MET, CD133, FUT4, ACVR1, mTOR, and KLF4 correlated positively with IARS2 expression, suggesting that IARS2 promotes metastasis via regulation ...

an ALK2 inhibitor. FOP is caused by a mutation in the gene for ALK2, which is known as ACVR1.

FOP is caused by a mutation in a gene known as ACVR1, which is involved in a cellular process that regulates the skeleton's development in the womb and repairs the skeleton throughout life.

INHA, INHBA, and follistatin are the major ligand subunits detected among the six examined in the bladder. ACVR1, ACVR1B, and ACVR2B are the major receptor subunits detected among the five examined in ...