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Autolus Therapeutics’ chimeric antigen receptor (CAR) T-cell therapy obecabtagene autoleucel (Aucatzyl) received FDA approval for adults with B-cell precursor acute lymphoblastic leukemia (ALL). The ...

1Louis V. Gerstner Jr. Graduate School of Biomedical Sciences, Memorial Sloan Kettering Cancer Center, New York, New York.

A new targeted therapy aimed specifically at FGFR3, TYRA-300, is showing preliminary promise in patients with advanced FGFR3-altered bladder cancer. Partial responses have been seen in an ongoing ...

According to research presented at the Society for the Immunotherapy of Cancer Annual Meeting in Houston, TX, the IL15 agonist NKTR-255 (Nektar Therapeutics) reverses lymphopenia caused by ...

Chimeric antigen receptors (CAR) enable MHC-independence but do not recreate the precise molecular regulation induced by T-cell receptor (TCR) complexes. In an effort to engage endogenous TCR circuits ...

Department of Thoracic Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China.

In preliminary results from the phase II iMMagine-1 trial released today, the BCMA-directed chimeric antigen receptor (CAR) T-cell therapy anitocabtagene autoleucel (anito-cel) did not elicit any ...

Mol Cancer Ther (2024) 23 (11): 1515.

1Program of Immunology and Immunotherapy, Cima Universidad de Navarra, Pamplona, Spain. 2Navarra Institute for Health Research (IDISNA), Pamplona, Spain. 3Centro de Investigación Biomédica en Red de ...

Deaths from cancer worldwide are estimated to reach 18.5 million in 2050, an 89.7% increase from the approximately 9.7 million deaths seen in 2022, researchers report (JAMA Netw Open 2024 Nov 5 [Epub] ...