The anti-Fas blocking antibody ZB4 and the Fas-ligand inhibitor failed to protect HT29 cells from CPT-induced apoptosis. Such a protection was obtained by transient expression of constructs ...

We therefore hypothesize that tumorigenesis may be driven by a combination of loss of mFasL-mediated apoptosis of cells undergoing transformation and sFasL/Fas-induced non-apoptotic signals ...

Furthermore, Akt activation is known to protect cells against apoptosis agents belonging to the TNF family of death ligands, such as Fas ligand (FasL) which acts through the Fas receptor (FasR). The ...

describes the development of novel Fas-TNFR chimeras acting as decoys for the Fas ligand and preventing it from binding to its natural receptor on the surface of chimeric antigen receptor (CAR) T ...

evidence has accumulated linking Aβ to neuronal apoptosis. In today's Journal of Neuroscience, researchers in Michael Greenberg's lab at Children's Hospital in Boston show that Aβ-induced neuronal ...

Apoptosis is the process of controlled cellular ... Through interaction between Fas and FasL (the Fas ligand), the DISC (death-inducing signaling complex) is formed. A feedback loop increases ...

One promising class of agents is the proapoptotic receptor agonists. Of these, recombinant human apoptosis ligand 2/tumor necrosis factor–related apoptosis-inducing ligand (rhApo2L/TRAIL)—an optimized ...

related apoptosis-inducing ligand (TRAIL) on apoptosis induction in tumor cells. Therefore, the prognostic relevance was analyzed of the expression of TRAIL and its death receptors DR4 and DR5 on ...