GPx1 overexpression prevented both the global and nuclear increase in activated ERK at 0.5 h after HPC and caused a significant decrease in phospho-ERK (pERK)/ERK levels at 24 h after HPC.

The E-NMDARs-induced tau overexpression was correlated with a reduced ERK phosphorylation, whereas the increased MEK activity, decreased binding and activity of ERK phosphatase to ERK, and ...

Further analysis of one cell line showed that adenovirally delivered PEA-15 overexpression inhibited cell growth and reduced DNA synthesis. They also found that activated ERK - a protein active in ...

Furthermore, this overexpression depended on HIPK2 retaining an intact kinase domain. It is well-known that ERK signaling protects the heart from stress-induced apoptosis, which is a key driver of ...

Oncogenic pathways downstream of EGFR, such as the PI-3-kinase–akt pathway, STATs, and the ras-MEK-ERK pathway, can be constitutively ... and vascular endothelial growth factor (VEGF) overexpression ...

One-fifth of patients in a phase 1 study responded to an investigational ERK inhibitor from Merck, bolstering hopes that this type of drug could be used effectively in combination with other ...

Further analysis of one cell line showed that adenovirally delivered PEA-15 overexpression inhibited cell growth and reduced DNA synthesis. They also found that activated ERK - a protein active in ...

Furthermore, this overexpression depended on HIPK2 retaining an intact kinase domain. It is well-known that ERK signaling protects the heart from stress-induced apoptosis, which is a key driver of ...

Further analysis of one cell line showed that adenovirally delivered PEA-15 overexpression inhibited cell growth and reduced DNA synthesis. They also found that activated ERK - a protein active in ...