Calmodulin (CaM) is a universal regulatory ... However, understanding of the structural mechanisms driving CaM regulation of full-length membrane proteins has remained elusive.

More information: Jui-Yun Chang et al, Mechanisms of Ca2+/calmodulin-dependent kinase II activation in single dendritic spines, Nature Communications (2019). DOI: 10.1038/s41467-019-10694-z ...

The mechanisms that result in synapse-specific activation of calcium/calmodulin-dependent protein kinase II (CaMKII) have been determined. CaMKII translocates to the synapse during long-term ...

However, the mechanism of sleep homeostasis in the brain ... Furthermore, they elucidated that the activation of calcium/calmodulin-dependent kinase II (CaMKII) *2, a protein phosphorylation ...

Researchers at UC have discovered a previously unknown mechanism that could explain ... a reduced interaction between a molecule called calmodulin and an ion channel (KCa3.1) in the immune cells ...

"It's really a very elegant mechanism," notes van Petegem. "Many channels are regulated by calmodulin but not in such a simple way." ...

The mechanism, which leads to the elimination of the overly permissive ion channel employs two proteins, α-actinin and the calcium-binding messenger protein calmodulin. Located on the neuron's outer ...

The research reveals how the calmodulin-like protein MdCML15 and ... a deeper understanding of iron uptake and regulation mechanisms in plants, which can lead to improved agricultural practices ...

The findings suggest that calcium-dependent calmodulin signaling is a protective mechanism used by pancreatic cancer cells in response to gemcitabine treatment and that calcium channel blockers ...

The activated kinase domains then phosphorylate each other, activity that persists even after the Ca2+/calmodulin becomes ... understanding of the molecular mechanisms of CaMKIIa activation." ...

During that period, he described calcium-calmodulin dependent protein kinase II and subsequently worked with Dr. Paul Greengard of Rockefeller University to examine the enzyme’s mechanism of ...