or in proteins involved in an earlier step in tRNA splicing—can lead to neurodevelopmental disorders. "Defects in other components of the tRNA pathway have been shown to be associated with ...

or in proteins involved in an earlier step in tRNA splicing -- can lead to neurodevelopmental disorders. "Defects in other components of the tRNA pathway have been shown to be associated with ...

or in proteins involved in an earlier step in tRNA splicing - can lead to neurodevelopmental disorders. "Defects in other components of the tRNA pathway have been shown to be associated with ...

The study shows that tiny pieces of RNA, called tRNA fragments, can cause problems in how the face develops in babies. This happens when tRNA is not processed properly. The issue affects special ...

Scientists have created a model to study the role of RNA splicing defects in Alzheimer's disease, revealing degeneration and toxicity caused by neuron hyperexcitability. Researchers have puzzled ...

Neurodegenerative diseases are commonly adult-onset conditions characterized by degeneration of specific neuronal populations. Familial forms are caused by mutations in single genes, but most ...

The findings appeared today in Nature Aging. The researchers used their new model to discover how defects in RNA splicing contribute to neurodegeneration in Alzheimer’s disease. RNA splicing is a ...

Using cryo-EM, researchers at Goethe University (Frankfurt, Germany) shed light on eukaryotic pre-transfer RNA (pre-tRNA) splicing, a key stage in protein production, and rationalize mutations ...

In one example, mutations in tRNA splicing endonucleases (TSEN), required for maturation of a subset of tRNAs, lead to intellectual disability. Since TSEN proteins are expressed in all cell types, an ...

In humans, the tRNA splicing endonuclease (TSEN) performs this task. The enzyme RNA kinase CLP1, which binds directly to TSEN, also plays a role in ensuring the correct conversion of tRNAs.