Phage T4 polynucleotide kinase/phosphatase (Pnkp) and RNA ligase 1 (Rnl1) are prototypal RNA healing and sealing enzymes. They function in vivo to repair a break in E. coli tRNA Lys triggered by phage ...
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A Novel Regulator of RNA Processing in Alzheimer's DiseaseThe study explains how the tRNA ligase complex (tRNA-LC), which is essential for digesting RNA molecules, is negatively regulated by the RTP801 factor. In a mouse model of Alzheimer's disease ...
reveal the mechanistic basis for the protective function of the oxidoreductase PYROXD1 that maintains the activity of the tRNA ligase complex under aerobic conditions. Understanding how RNA folds ...
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