The third base of a codon can form non-standard base pairs with the first base of the anticodon, allowing for more flexibility in codon recognition. Wobble base pairing enables a single tRNA molecule ...

Jose Lora, Ph.D., Chief Science Officer of hC Bioscience, unveiled the company’s first development candidate, HCB-101, an anticodon engineered tRNA designed to suppress nonsense mutations.

tsRNAs include tiRNA and tRF. Under stress, angiogenin cleavage of the tRNA anticodon loop generates tiRNAs that are further categorized as 5′ tiRNA and 3′ tiRNA. Collectively, these findings ...