microRNA (miRNA) and small interfering RNA (siRNA), which bind to messenger RNAs (mRNA) to up- or downregulate their activity. This system is of utmost importance in protecting the organism from ...

Small interfering RNA (siRNA) and microRNA (miRNA) are small RNAs of 18-25 nucleotides (nt) in length that play important roles in regulating gene expression. They are incorporated into an RNA ...

siRNA is a double-stranded RNA molecule that is non-coding. It is also known as silencing RNA and short interfering RNA. It is similar to microRNA (miRNA) and the structure is short and well ...

mimic miRNA, and antimiR. According to publications, high siRNA concentrations during transfection may result in non-specific off-target effects. Using as little siRNA as possible can improve the ...

In such cases, Sylamer is used to first establish whether any miRNA or siRNA has a significant effect on mRNA levels and to choose an appropriate threshold. If a clear enrichment peak is found ...

"The degree of complementarity of a miRNA/siRNA to its target site determines whether RISC complex enters into either miRNA-type or RNAi-type repression pathway," Wang tells Phys.org. (The RNA ...

View Full Profile. Learn about our Editorial Policies. The natural RNAi mechanism can be directed by either short interfering RNA (siRNA) or microRNA (miRNA). 1 There are four key steps in the RNAi ...

Here we show a potent combination of microRNA and siRNA delivered by an efficient nanocarrier to PDAC tumors. Using proteomic-microRNA profiles and survival data of PDAC patients from TCGA ...

Sirna Therapeutics, Inc. has announced that it has signed an exclusive worldwide licensing agreement with the University of Massachusetts Medical School (UMMS) for the rights to patents covering ...

Silence's clinical siRNA product pipeline is one of the broadest ... using its proprietary lentiviral-based miRNA expression library, currently the largest available. This approach results in ...

"Therapeutic siRNA drugs don't work well enough against ... for their joint discovery of microRNA and its role in gene regulation in the early 1990s. Dr. Lai did his undergraduate thesis research ...