VPS72 has been identified as a key genetic player in liver cancer, highlighting its role in altering fat metabolism.

"Our study has not only identified p62 phosphorylation as the initiating signal, but elucidates ... drugs that exclusively target the mTORC1 activation pathway, potentially circumventing the ...

"We started at the mTORC1 kinase and are building the pathway up piece by piece to identify ... major indirect negative regulators of mTORC1 signaling. Upstream of the mTORC1 complex are several ...

Deleting the TSC2 gene in specific lung cells of mice led to the activation of the mTORC1 signaling pathway and pulmonary disease characteristics consistent with human LAM disease, particularly in ...

Only recently have scientists begun to tease apart the molecular links between specific nutrients and mTORC1, a cellular signaling pathway that controls growth and metabolism. Now Whitehead ...

PI3K/AKT/mTOR signaling pathway showing interacting activation and regulatory ... mTOR activity in the cell is carried out by two distinct complexes. mTORC1 complex is made up of mTOR, raptor, mLST8, ...

However, deleting mTORC1 signaling in these cells at E12.5 lengthened the nasal ... be interpreted that you need to have a high-protein diet.” Chagin added that the pathway is likely an adaptive ...

The protein complex mTORC1 is a convergence point for multiple signaling pathways that control cell growth and proliferation. These pathways sense the presence or absence of growth factors ...

There are 4 main functions of the mTOR signaling pathway: cell growth and proliferation ... There are two different mTOR complexes: mTORC1 and mTORC2. They have slightly different proteins ...