The mammalian target of rapamycin (mTOR), a phosphoinositide ... We presume that, although the TOS motif, and possibly others, is the primary means of substrate recruitment, the secondary site ...

It contains the atypical kinase mTOR and the RAPTOR subunit that binds to the Tor signalling sequence (TOS) motif of substrates and regulators. mTORC1 is activated by the small GTPase RHEB (Ras ...

The enzyme PI3 kinase is activated by phosphorylation PI3 kinase phosphorylates the substrate PIP2 into PIP3 PIP3 activates the enzyme Akt, which then activates the protein mTOR Then, mTOR ...

The inhibition of tumor growth in the xenografts and cell lines depended upon the strong inhibition of phosphorylation of mTOR substrate eIF4E binding protein 1 (4EBP1) but was not correlated with ...