eFFECTOR’s STRI product candidates target the eIF4F complex and its activating kinase, mitogen-activated protein kinase interacting kinase (MNK). The eIF4F complex is a central node where two of ...

eIF4E is a component of the eIF4F complex, which ... San Francisco in collaboration with eFFECTOR. The eIF4E target is the subject of eFFECTOR’s collaboration with Pfizer.

eFFECTOR’s STRI product candidates target the eIF4F complex and its activating kinase, mitogen-activated protein kinase interacting kinase (MNK). The eIF4F complex is a central node where two of ...

How TC and eIF4F assembly are coordinated ... Accordingly, eIF2β mediates the effect of mTORC1 on protein synthesis and proliferation. In addition, we demonstrate a formerly undocumented role ...

The expected effect (E exp) of the combination was estimated ... terminal and carboxy-terminal halves of eIF4G, respectively. eIF4F complex formation using the cap-binding assay was assessed ...

Effector is set to receive $15 million upfront ... pateamine A and silvestrol act on other parts of the eIF4F complex, which includes the cap-binding protein eIF4E. Yet eIF4E has proven to ...