icr.ac.uk15d
New research might make an ‘undruggable’ target druggable – leading to new cancer drugs
The target, eukaryotic initiation factor 4E (eIF4E), is essential for the production of proteins linked to cell growth in a several tumour types – including breast and prostate cancer. Blocking this ...
Hosted on MSN1mon
Dopamine linked to autism symptoms in mouse model study
The study focuses on a mouse model of ASD with elevated levels of eukaryotic initiation factor 4E (eIF4E), a protein that plays a crucial role in the process of translating genetic information ...
The Scientist3mon
A Keto Diet Could Enhance Cancer Drug Effectiveness
Previously, Ruggero found that mice that were fasting or on a ketogenic diet exhibited increased phosphorylation of a protein called eukaryotic translation initiation factor (eIF4E), which helped the ...
Nature6y
35 years later, mRNA caps still matter
The cap was found to have a crucial role in mRNA translation, and eukaryotic translation initiation factor 4E (EIF4E) was the first protein identified to bind directly to the cap to recruit ...
EuropaWire15d
Breakthrough Discovery Targets Undruggable Cancer Protein, Opening Doors for New Treatments
Researchers have made a significant breakthrough in cancer drug discovery by identifying a new binding site on the eukaryotic initiation factor 4 ...