Nucleotide exchange on eIF2 is then performed by interactions with eIF2B, the nucleotide exchange factor, preparing eIF2 for a new round of translation initiation. The majority of the eIFs consist ...

2012;7(1):81-92. These recent findings have two important implications. First, simple measurements of eIF2B GEF activity in samples from patient-derived cells do not appear to be a suitable ...

They have demonstrated a way to observe the molecular mechanism that switches control of activation of eIF2 by eIF2B when a cell undergoes stress. In their paper published in the journal Science ...

Jan. 06, 2025 (GLOBE NEWSWIRE) -- Denali Therapeutics Inc. (NASDAQ: DNLI) today announced topline results from an analysis of Regimen G of the Phase 2/3 HEALEY ALS Platform Trial evaluating eIF2B ...

Vanishing white matter (VWM) is caused by mutations in the genes for eIF2B, an important regulator of protein synthesis. VWM mutations affect the function of eIF2B in diverse ways; recent data ...

Healey & AMG Center in collaboration with the Northeast ALS Consortium (NEALS) completed enrollment for Regimen G of the Phase 2/3 HEALEY ALS Platform Trial, which evaluates Denali’s eIF2B ...