CHICAGO -- Intracerebroventricular (ICV) delivery of bivalent CAR T-cells targeting EGFR and IL13Rα2 was feasible and ...

To search for such mutations, we first looked for rearrangements within the extracellular domain of EGFR that are characteristic of gliomas 15; none were detected. We therefore sequenced the ...

particularly in the ATP-binding pocket of EGFR's tyrosine kinase domain. For gefitinib, well-known mutations like Thr790Met were identified, along with previously uncharacterized mutations near ...

Cancer cells may acquire the capacity for autonomous and dysregulated proliferation through the uncontrolled production of specific molecules that promote cell growth (growth factors) or through ...

We explored the possible roles of PTEN methylation and mutation of the EGFR L2 domain, which is the site of binding to cetuximab, in cetuximab resistance in KRAS wild-type mCRC. Methods: The subjects ...