More information: Lijuan Deng et al, Identification of CDKN1A as a potential key risk factor in MASLD progression, The FASEB Journal (2025). DOI: 10.1096/fj.202402942R Provided by Federation of ...

and represses expression of Cdkn1a, a cyclin-dependent kinase inhibitor that negatively regulates the G1–S transition. We identify protein domains required for Trim71 association with Argonaute2 ...

Finally, Cdkn1A protein and transcript levels were upregulated in mouse cells treated with fatty acids and in mouse models of MASLD. The study's results are consistent with previous reports ...