Addex Therapeutics (SIX/NASDAQ: ADXN), a clinical-stage biopharmaceutical company focused on developing a portfolio of novel ...

There is a large intracellular loop between TM3 and TM4, which is the most dissimilar part of the sequence within the GABA A receptor subfamily. When considering the GABA activation sites ...

Based on evidence from research on the receptors’ function in the brain and the drugs that can activate or inhibit them, the authors propose possible mechanisms by which GABA-modulating ...

GABA receptors on nerve cells receive the chemical messages that help to inhibit or reduce nerve impulses. Prescription medications called benzodiazepines bind to and then enhance GABA expression ...

A new study spanning known data about the neurotransmitter GABA and its principal receptors showcases evidence of the receptors' importance in depression and potential as therapeutic targets.

Researchers have long sought structure determination of the receptor to better understand the target and pursue more rational drug design. GABA A receptors are a family of pentameric chloride ion ...

They all tweak the activity of GABA-A receptors. When engaged by their physiological ligand, the inhibitory neurotransmitter γ-aminobutyric acid (GABA), the receptors provide a channel for chloride ...

A new article in Biological Psychiatry examined whether during the extinction of fear learning, GABA receptors may be inserted into the cell surface to reduce the excitability of the amygdala.

The new wave of GABA drugs, by contrast, work as modulators. They target only certain receptors, which lets drug makers more delicately balance the flow of the neurotransmitter in the brain.

Contrary to previous research, γ-aminobutyric acid type A (GABA A) receptors are not deficient in the brains of adults with autism spectrum disorder (ASD), although GABA signaling may be ...