1). Among these were the components of the E3 ubiquitin ligase complex, CUL5, ELOB and ELOC, known to interact with Vif and trigger A3G degradation 4,5,6,8,9,10. Although the RING-box protein RBX1 ...

thus supporting our results described below. Here we describe studies of the mechanism by which Vif neutralizes APOBEC3G. We confirm that APOBEC3G efficiently inactivates HIV-1(Δvif) and that its ...