Tainer says, "The exonuclease domain of the WRN protein is a prime example of what we in SBDR call 'master keys,' structures that open doors to lots of different repair pathways. Among other ...

Tainer says, "The exonuclease domain of the WRN protein is a prime example of what we in SBDR call 'master keys,' structures that open doors to lots of different repair pathways.

Previous studies indicated that males lacking the helicase domain of the Wrn protein orthologue exhibited hepatic transcriptomic and metabolic alterations. In this new study, researchers Lucie ...

Previous studies indicated that males lacking the helicase domain of the Wrn protein orthologue exhibited hepatic transcriptomic and metabolic alterations. In this new study, researchers Lucie ...

which generates the WRN protein. Previous studies showed that the normal form of the protein is an enzyme that maintains the structure and integrity of a person's DNA. When the protein is mutated ...

Sinclair and his colleagues have evidence that they may be doing this by coopting the WRN protein, which is thought to stabilize telomeres, though not actually build them. The researchers found ...

identified a protein in cancer cells, WRN, as being a vulnerability in MSI cancers. Since then, the team has shown that cancers resistant to standard-of-care therapies, including immunotherapy ...

The WRN protein is basically a longevity molecule, Sinclair explains. "Cancer cells may utilize the WRN protein for their own purposes to become immortal and get around the barrier to ...