Here, we set out to further define WRN function through detailed characterization of the novel WRN exonuclease domain (WRN-exo). We report five crystallographic structures of human WRN-exo at up ...

Researchers have discovered key mutations in certain cancer cells that make them resistant to WRN inhibitors, a new class of anti-cancer drugs. The yet-to-be-published findings are presented on ...

Dr. Gabriele Picco, senior staff scientist and project lead in Dr. Garnett's lab, told the Symposium, "WRN inhibitors function through a mechanism called synthetic lethality, where two non-lethal ...