Now, researchers at the University of Tsukuba have illustrated how mutations in a specific gene called VAV1 may promote tumors involving a type of white blood cell, the T-cell, in experimental mice.

Vav1 has been known to be involved in alterations in gene expression in the immune system, where it is physiologically expressed. Vav1 was discovered a few years ago by Katzav-Shapira when she was ...

NKG2D is an important immunosurveillance receptor that responds to stress-induced ligand expression on tumors ... partner Grb2 and the effector molecule Vav1 (Grb2-Vav1) to DAP10 was sufficient ...

Now, researchers at the University of Tsukuba have illustrated how mutations in a specific gene called VAV1 may promote tumors involving a type of white blood cell, the T-cell, in experimental mice.

The data demonstrate that MRT-6160, a novel, highly selective MGD targeting VAV1, attenuated disease progression in a murine collagen-induced arthritis (CIA) model. In vitro, MRT-6160 induced ...

Reorganization of the actin cytoskeleton is pivotal in influencing cellular responses to extracellular ... we measured cell surface TCR expression of Jurkat T cells transfected with control ...