Leg cramps—often referred to as a charley horse—are painful, involuntary contractions of the muscles in your thigh or calf. They commonly occur from dehydration or muscle overexertion.

If you’ve ever experienced leg cramps at night, you know they’re no joke. They can rudely interrupt your sleep and startle you awake with a jolt of pain. Although they’re quite common ...

If you have nocturnal (nighttime) leg cramps, your doctor might prescribe quinine (Qualaquin)-even though the U.S. Food and Drug Administration has approved it for only one purpose: to treat ...