After analyzing this large data sample, they have a more thorough understanding of how the TP53 gene mutation impacts cancer. The team found that across all cancer types studied, TP53 mutations were ...

PHILADELPHIA - Rare inherited mutations in the body's master regulator of the DNA repair system - the TP53 gene - can leave people at a higher risk of developing multiple types of cancer over the ...

Structural studies classified common TP53 mutations into two types: contact mutations, which affect DNA-binding amino acids, and structural mutations, which destabilize the protein’s DBD.

Mutations in APC, TP53, KRAS, and PIK3CA genes have been frequently ... Genome analysis for each cancer type can guide treatment selection and help improve the outcomes of patients with CRC." ...

Table 3 presents the relative frequencies of cancer types showing strong, moderate or weak associations with germline TP53 mutations in relation to their population expected frequencies.

When TP53 is mutated, the protein made from this gene, called p53, can no longer perform this protective function, and the result can be cancer. Across many cancer types, mutations in TP53are ...

Patients with myelofibrosis (MF) with single-hit mutations had similar outcomes to patients with wild-type TP53. People with myelofibrosis (MF) who undergo hematopoietic stem cell transplantation ...

Over the course of treatment, patients with relapsed/refractory acute myeloid leukemia (AML) may acquire new TP53 mutations, making ongoing monitoring for mutations crucial. “New novel therapies ...

But mutations in TP53 commonly develop in cancers ... Although the syndrome is associated with many different types of cancer, including some in breast, bone and soft tissues, such as muscles ...

A rare genetic mutation in a European sperm donor has reportedly caused cancer in 10 children, highlighting the need for ...

After analyzing this large data sample, they have a more thorough understanding of how the TP53 gene mutation impacts cancer. The team found that across all cancer types studied, TP53 mutations ...