NGF can activate TrkA on sympathetic neurons, which triggers sprouting of sympathetic nerves and the release of catecholamines, which interact with sensory neurons and cause ectopic nerve firing.
This is done to evoke neurotrophic or pro-apoptotic signaling. NGF binds to TrkA; BDNF and neurotrophin 4 bind to TrkB; neurotrophin 3 binds to TrkC. BDNF, NGF, and all the receptors are known as ...
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