Lipid nanoparticle platform delivers mRNA to the brain
New lipid nanoparticle platform delivers mRNA to the brain through the blood-brain barrier
Scientists have developed a lipid nanoparticle system capable of delivering messenger RNA (mRNA) to the brain via intravenous injection, a challenge that has long been limited by the protective nature of the blood-brain barrier.
Get Instant Summarized Text (Gist) The blood-brain barrier, a protective shield for the brain, poses a significant challenge for delivering medications to treat neurological diseases. Recent ...
The blood–brain barrier (BBB) is meant to protect the brain from noxious agents; however, it also significantly hinders the delivery of therapeutics to the brain. Several strategies have been ...
ABL Bio’s first-in-class bispecific antibodies for Parkinson’s disease combine unprecedented blood–brain barrier penetration with a robust mechanism of action for improved therapeutic efficacy.
This important study examines the role of pericytes in patterning the zebrafish blood-brain barrier (BBB) and controlling its permeability. Using pdgfrb mutant zebrafish models lacking brain pericytes ...
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Researcher develops method to measure blood-brain barrier permeability accuratelyTTUHSC’s Quentin R. Smith, Ph.D., and a team of researchers investigated methods to accurately measure drug permeability across the blood-brain barrier. For decades, scientists across the globe ...
The Mt. Sinai study could open the door to future therapies for Alzheimer’s, amyotrophic lateral sclerosis, brain cancer, and ...
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