The team turned to a precision nuclear run-on sequencing technique called PRO-cap, which allowed them to determine the start site of transcription in DNA by sequencing the corresponding first few ...

Most pol II genes have a TATA box (consensus sequence TATTAA) 25 to 35 bases upstream of the initiation site, which affects the transcription rate and determines location of the start site.

Some transcription factors bind to a DNA promoter sequence near the transcription start site and help form the transcription initiation complex. Other transcription factors bind to regulatory ...

A comprehensive catalog of transcription factor binding sites has been developed, enhancing the understanding of gene regulation and its link to diseases like cancer and developmental disorders.

The lab of Dr. Mark Magnuson, Louise B. McGavock Professor and professor of molecular physiology and biophysics at Vanderbilt ...

Torsional stress in chromatin plays a fundamental role in cellular functions, influencing key processes such as transcription, replication, and chromatin organization. Transcription and other ...