Double-edged STING: A new pathway involved in aging
They found that when STING was activated, two transcription factors called TFEB and TFE3 were shuttled to the nucleus of ...
News Medical16d
TFE3 activation shows promise for counteracting Parkinson's disease pathology
This dual action—targeting both protein aggregation and mitochondrial dysfunction—positions TFE3 as a promising therapeutic candidate for Parkinson's disease. By bolstering the brain's natural ...
Baylor College of Medicine2y
TFEB and V-ATPase-mediated Lysosomal Stress Sensing Pathway in Tauopathy
Early work revealed that TFEB is highly effective in ameliorating tau/NFT pathology and rescuing cognitive impairment and neurodegeneration. TFEB targets only the aberrant tau species and this ...
AZoLifeSciences on MSN5mon
A Novel Function for STING in DNA Damage Response
Their findings revealed that upon STING activation, the transcription factors TFEB and TFE3 were translocated to the nucleus, ...