This compound decreased tau accumulation and ameliorated cognitive dysfunction in mouse models of tauopathies. Tau is a soluble protein expressed mainly in neuron axons that binds tubulin and ...

Studies with two mouse models that overexpress different forms of tau found, for the first time, that elevated levels of the protein were associated with a significant reduction in neural activity ...

Mouse and rat model firm Taconic and tau oligomer-focused company Oligomerix are putting their heads together to evaluate the Taconic tau mouse model as a tool for preclinical testing of compounds ...

An anti-tau treatment called epithilone D (EpoD) was effective in preventing and intervening the progress of Alzheimer's disease in animal models, improving neuron function and cognition ...

While tau-targeting drugs have looked promising in mouse models, they've failed in clinical trials. A recent study published in Molecular Neurodegeneration led by Kathrin Wenger, a Ph.D. student ...

Seeding activity was first detected at 1.5 months of age in these mice, indicating that proteopathic tau seeding is an early phenotype in this model (Holmes et al., 2014). Behaviorally, PS19 mice ...

What’s the answer? Perhaps tau. APP knock-ins, like most APP overexpression models, lack tau neuropathology and neurodegeneration, defining aspects of human AD. The mice appear to model early, amyloid ...

Dr. Dan Frenkel of TAU’s neurobiology department, working with Prof. Yaniv Assaf and doctoral student Hilit Levy, is likely to boost research by producing a better model. The team discovered ...