Not the Same. In amyloid-negative people (left) few tangles accumulate over a decade. In amyloid-positives (right), tangles grow faster in women (red) than men (blue). [Courtesy of Gillian Coughlan, ...

New mouse model of tau propagation Tokyo Metropolitan Institute of Medical Science Journal Brain Communications Funder Core Research for Evolutional Science and Technology, Japan Society for the ...

When under stress, neurons crank out tau fragments, and many scientists blame this for the propagation of tangle pathology in Alzheimer’s disease. The fragments also directly compromise synapses they ...

"Assembled tau associates with EVs in the central nervous system of individuals with AD, which is linked to its clearance and prion-like propagation. However, the identities of the assembled tau ...

However, it had been nearly impossible to model tau propagation in these young neurons, as tau propagation requires decades in aging brains. Dr. Gan's team used CRISPR technology to modify the ...

Tau is a protein that builds up and moves between nerve cells in the brains of people living with Alzheimer’s disease, causing damage. Professor Mudher is using clever genetic manipulation in fruit ...