The insulin- and growth factor-stimulated protein kinases protein kinase ... have indicated that the tumour suppressor tuberous sclerosis complex-2 (TSC2) functions as an antagonist of S6K ...

The TSC1 and TSC2 gene products form a functional complex that has GTPase-activating protein (GAP) activity toward Ras homolog enriched in brain (Rheb) to inhibit mammalian target of rapamycin ...

Loss of heterozygosity at the TSC1 or TSC2 locus and hyperphosphorylation of ribosomal protein S6 have been documented ... and that the TSC1–TSC2 complex regulates the differentiation of cells ...

Biallelic (complete) loss of TSC1 or TSC2 leads to the loss of negative regulatory effects of the TSC protein complex and constitutive activation of mTORC1. CAD denotes carbamoyl-phosphate ...

The TSC1 protein and the TSC2 protein together form the TSC protein complex. This has the task of controlling cell growth and, as a result, of suppressing the emergence of tumors - hence the term ...

tuberous sclerosis complex 2 (TSC2), preventing it from connecting with yet another protein TSC1, that keeps mTOR in check. Treating the genetically engineered mice with rapamycin, a drug that ...

Activated AKT phosphorylates TSC1/2 and ... GPCR, G-protein coupled receptor; GSK3β, glycogen synthase kinase 3β; mTORC1/2, mammalian target of rapamycin complex 1/2; PDK1, phosphoinositide ...