TRPML1 is a key lysosomal ion channel that is believed to play a role in lysosomal function by promoting autophagy and lysosomal exocytosis. Alterations in TRPML1 function have been implicated in ...

TRPML1 is important for lysosomal health, and mutations in the TRPML1 gene cause a severe childhood neurodegenerative disease. When TRPML1 is activated, it releases calcium from the lysosome and ...

This pathway is mediated by the activation of TRPML1, lysosomal zinc ion release, and mitochondria dysfunction.

which encodes a protein that transports low-density lipoproteins to lysosomal compartments. Without the protein, the cells accumulate excess lipids in late endosomes and show signs of NPC. The ...

Previous research demonstrated that female mice lacking the gene Mcoln1, which encodes lysosomal protein TRPML1, become infertile by five months of age due to degeneration of the corpus luteum (CL).

The startup was subsequently supported by Avalon’s COI Pharmaceuticals incubator, equipping it to build on research into links between lysosomal ion channel TRPML1 and diseases. At launch ...

All four presentations were made at the 18 th Annual WORLDSymposium™, held February 7 – 11, 2022, in San Diego, CA. Data from the ... and non-lysosomal glucosylceramidase (GbA2).