Transient receptor potential mucolipin 1 (TRPML1) is a Ca 2+-releasing cation channel that mediates the ... a 3.72-Å apo structure at pH 7.0 in the closed state, and a 3.49-Å agonist-bound ...

The interdisciplinary team solved the structure of the mouse TRPML1 (transient receptor potential mucolipin 1) ion channel. Their study, published online by Nature, comes just a week after three ...

The interdisciplinary team solved the structure of the mouse TRPML1 (transient receptor potential mucolipin 1) ion channel. Their study, published online by Nature, comes just a week after three ...

One ion channel in particular—the Transient Receptor Potential Channel Mucolipin-1 (TRPML1)—has been linked to LSDs. The Trpml1 gene encodes an iron and calcium ion channel expressed in late endosomes ...

Its candidates are small-molecule agonists of TRPML1, a calcium channel found in lysosomes, the enzyme-filled sacs that break down cellular debris. TRPML1 is important for lysosomal health ...

TRPML1 is a protein channel that ferries metal ions, including iron, zinc and calcium, across the lysosome membrane and into the cell. The researchers examined protein expression levels of TRPML1 ...

Calporta develops selective small molecule agonists to transient receptor potential cation channel, mucolipin subfamily, member 1 (TRPML1), also called mucolipin-1, based on research from the lab ...