Mutations in genes of the NOTCH pathway and tumor suppressor genes (TP53/CDKN2A), but not individual genes, conferred an unfavorable prognosis, confirmed in the independent validation cohort.

Mutations in APC, TP53, KRAS, and PIK3CA genes have been ... pathway genes, PTEN, and NOTCH pathway genes; these mutations likely contribute to tumor survival and maintenance.

"Our results highlight the differential genomic and epigenomic alterations in PAX, NOTCH, and TP53 pathways between African-American and non-Latino white HNSCC patients, which underlie the complex ...

Mutations in the gene TP53 were also found to facilitate ARF6 activation, in addition to causing a metabolic pathway, called the mevalonate pathway, to go into overdrive. This pathway is known for ...

For example, MDM2 binds to TP53 mRNA, controlling the rate of translation ... The biological effects of p53 pathway variants at the molecular level in primary cells or in vivo still need to ...

Studies to improve the predictive value of genetic and genomic modifier effects on the mutant TP53-associated phenotype will inform development of more refined tumor screening protocols and lead to ...

Almost all women with HGSC have mutations in the gene TP53, which is responsible for ... "This unique finding paves the way for identifying the pathways involved in cancer progression, leading ...

A cell signaling mechanism of fundamental importance to animal development is the Notch pathway (Figure 1). It may be safely said that Notch signaling is required, in some reasonably direct fashion, ...

They found that mutations in KRAS increased the production of two proteins, called ARF6 and AMAP1, which they previously discovered constitute a signalling pathway involved in cancer cell invasion and ...