A rare genetic mutation in a European sperm donor has reportedly caused cancer in 10 children, highlighting the need for ...

In Greenland sharks, a portion of its TP53 gene sequence is altered from how it typically functions in other animals. Using an AI model, the researchers predicted that the mutation could impact ...

Geneticists from KU Leuven, Belgium, have shown that tumour protein TP53 knows exactly where to bind to our DNA to prevent cancer. Once bound to this specific DNA sequence, the protein can ...

The debate over how often a donor’s sperm should be used to conceive children has been reignited in Europe, after 67 children ...

In addition to TP53, sequencing showed osteosarcoma tumors ... All but one of the tumors had at least one structural variation in a cancer gene. The list included recurring mutations in the ...

The matter came to light after two families approached their fertility clinics upon discovering their children had cancer.

Specific mutational hotspots for TP53 missense variants in the DBD are observed in cancer. This is partly due to the high susceptibility of certain DNA sequences to mutagenic processes and ...

Now, a team of researchers from Xi’an Jiaotong-Liverpool University (XJTLU) and other research institutes across China have published a study in which they engineered a short sequence of artificial ...

ChenWei Lin and Regine M Schoenherr, staff scientists in Dr. Amanda Paulovich’s lab in the Translational Science and Therapeutics Division at Fred Hutch, the authors generated RNA sequencing ... PTEN ...

A sperm donor unknowingly carried a rare, cancer-causing TP53 gene mutation, leading to at least 67 children conceived across ...