We’re witnessing a renaissance in cytokine targeting,” says Dr. Emily Rhodes, immunologist at the Stanford Institute for ...

Pro-inflammatory signaling molecules in MS cause problems with the growth and development of myelin-making cells in the brain ...

Some newer biologics also function as DMARDs and have been approved ... pathways and are administered by injection or infusion. TNF-alpha is a substance that occurs naturally in the body.

Cite this: TNF Signaling Inhibition in the CNS: Implications for Normal Brain Function and Neurodegenerative Disease - Medscape - Oct 17, 2008.

6 Isomyosamine is a novel plant alkaloid small molecule shown to regulate the immuno-metabolic system through the modulation of numerous pro-inflammatory cytokines including TNF-alpha (TNF-α), an ...

When the workload on the heart increases, the ventricular wall may thicken too, known as cardiac hypertrophy. This is an ...

including tumor necrosis factor-alpha (TNF-α) (P=0.008), Interleukin-6 (IL-6) (P=0.03) and soluble TNF-α receptor 1 (sTNFR1) (P=0.02) at several timepoints throughout the 28 days of treatment.

today announced the initiation of a fully funded Phase 2b clinical trial evaluating oral TNF-alpha (TNF-α) inhibitor drug candidate isomyosamine as a treatment for chronic inflammation associated ...