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Complex interactions between nucleic acid sensors and enzymes in immune cells explained
A denosine deaminase 2 (ADA2) has been identified as a regulator of toll-like receptor 9 (TLR9) activation in response to nucleic acids, according to a recent study. ADA2, previously known for its ...
Nature5y
Oligonucleotide IRS 954 might represent a novel therapy for SLE
TLR7 and TLR9 are also thought to be involved in B-cell-mediated production of autoantibodies specific to nucleic acids, thereby triggering and then promoting SLE. Barrat et al. have described ...
Nature5y
PAMPs and DAMPs in the inflammatory response
Similar to the release of bacterial DNA following sepsis, the mitochondrial DNA released by severe trauma can also act through the toll-like receptor-9 (TLR9) to activate neutrophils by activating ...