we showed that Tcf7l2 transcriptional activity is crucial for OL myelination and remyelination. We further conducted genome-wide chromatin immunoprecipitation sequencing (ChIP-seq) profiling to ...

BUFFALO, N.Y. — Remyelination, the spontaneous regeneration of the fatty insulator in the brain that keeps neurons communicating, has long been seen as crucial to the next big advance in treating ...

The role of the extracellular matrix is being increasingly appreciated as a key variable in MS that can determine whether or not remyelination will occur after it has been damaged. “In multiple ...

Obesity leads to changes in the splicing pattern of metabolically relevant genes such as TCF7L2 and INSR, resulting in impaired insulin action. However, weight loss, induced by either obesity ...

Researchers are reporting what they call "the first clinical study to show evidence of proof of biology for remyelination in multiple sclerosis [MS] with a drug therapy." The research team from ...

Although the pathology of demyelination is easy to see, the biology of demyelination and remyelination is poorly understood. Drug therapy to prevent demyelination are available, but there are no ...

An experimental monoclonal antibody for multiple sclerosis (MS) that enhances remyelination has shown promise in phase 1 studies. The emerging safety, tolerability and pharmacokinetics data for ...

Biogen Idec ($BIIB) highlighted positive data from its mid-stage study of anti-LINGO-1, a closely watched drug that raises the potential for spurring remyelination ...