Recently, it has been elucidated that a subset of CD4 + T cells known as T follicular helper (Tfh ... critical to germinal-center formation and function. In mice and humans, these cells are ...

This article explores the role of helper T cells in health and disease. While they have no direct involvement in neutralizing foreign substances, CD4+ T cells have various functions that help ...

Our studies here indicate that the initial strength of TCR binding also regulates the function of antigen-specific effector helper T cells. TCR with stronger pMHCII binding 'preferentially' drive ...

The cytokine profile (including key cytokine receptors as denoted by R), the effector cell type that is activated, and the corresponding types of infections are shown for each Th subgroup.

They are modulated by inflammatory mediators, and they are distinct for different subgroups of T cells (for example, type 1 and type 2 helper T cells ... but also many function as tissue-specific ...

The study was published in Nature Immunology. "We found a cytokine in a subset of T helper cells, the Th17 cells, that was previously known to be part of the innate immune system," explains study ...

A study initiated by a University of Arizona Comprehensive Cancer Center physician-scientist defined for the first time how ...

A newly identified rare cell subset that drives immune tolerance in dietary and gut microbiota may offer a new therapeutic ...

Antibodies bind to targeted proteins to both prevent their function and attract immune ... A different group of immune cells, called T follicular helper cells, activate B cells in lymph nodes.

CD4+ T cells, or helper T cells, are one type of lymphocyte ... They carry out multiple functions ranging from activation of B-lymphocytes, cytotoxic T cells, as well as nonimmune cells.

An inefficient helper T cell response might explain why some patients relapse after clearing the infection. "If CD4+ T cells have an immune surveillance function, as suggested by our findings ...