siRNA is a double-stranded RNA molecule that is non-coding. It is also known as silencing RNA and short interfering RNA. It is similar to microRNA (miRNA) and the structure is short and well ...

Encapsulated in lipid nanoparticles (LNPs), siRNA can be delivered efficiently to target cells. However, the effectiveness of these therapies hinges on the internal structure of the LNPs ...

Recent publications analyzing the relationship between local free energy and siRNA efficiency 4,5 have demonstrated that mRNA target site secondary structure is of great importance for siRNA ...

However, depending on the structure and sequence of a siRNA and how it is delivered, it may induce a potent innate immune response in humans, stimulating the release of inflammatory chemicals such ...

Nanomedicine. 2014;9(1):105-120. Overall, HDL-based siRNA delivery possesses many attractive features, including ultra-small size, favorable surface properties (no PEGylation is required for ...

leading to destabilization of the helical structure of the mRNA, causing denaturation or separation of the strands. Without strand formation, the binding to the seed region of siRNA is difficult ...

leading to destabilization of the helical structure of the mRNA, causing denaturation or separation of the strands. Without strand formation, the binding to the seed region of siRNA is difficult ...

Dr. Yamada and Khvorova, however, took a different approach, homing in on the carbon molecules in the backbone's chemical structure ... making a big impact on siRNA's durability by increased ...

Using NMR and small-angle X-ray scattering (SAXS), researchers revealed that different preparation methods affect the internal structure and siRNA distribution in LNPs, impacting their therapeutic ...

Preliminary data underlines the correlation between the siRNA knockdown efficiency and the local free energy of the mRNA target site. There is a strong evidence that considering the mRNA secondary ...