Researchers found that the Wnt5a protein, secreted by inflammatory fibroblasts within cancerous tumors, inhibits angiogenesis and consequently promotes hypoxia within tumors. Hypoxic conditions help ...

The altered cells release factors that help tumors grow, such as epiregulin. In addition, they release Wnt5a protein, which helps maintain a low-oxygen state by inhibiting new blood-vessel ...

In structure, cortactin contains a SH3 domain ... More information: Kamrul Hasan et al, Impact of cortactin in cancer progression on Wnt5a/ROR1 signaling pathway, Oncotarget (2023).

The researchers grew melanoma cells together with human skin or lung fibroblasts -- common cells that help maintain the structure of tissue ... that regulated WNT5A, a protein involved in various ...

It’s a special skin structure between their limbs called a ... We discovered that levels of a gene called Wnt5a are strongly correlated with the onset of those early skin changes ...

The research team found that when oxygen becomes scarce in certain areas of a colon tumor, the surrounding fibroblasts (normally ‘good’ cells that support tissue structure) transform into ...