A protein called STING, previously shown to control a pathway that contributes to antiviral signaling, also plays an important role in cellular stress clearance and cell survival, according to a ...

The cGAS-STING signaling pathway, a key element of the innate immune response, has risen as a promising avenue to amplify this therapeutic approach. Unraveling the pathway's role in immune system ...

Scientists have uncovered a surprising trick used by the herpes simplex virus to wake up inside the body. Researchers at the ...

Additionally, it incorporates ovalbumin (OVA) as a model antigen to boost vaccine-like immune responses, and importantly, it activates the cGAS-STING signaling pathway, a key player in innate ...

Triggered by an enzyme called DNA protein kinase (DNA-PK), the newly found pathway is independent of the cGAS-STING pathway—until now considered the main regulator of mammalian innate immune responses ...

As they dissected the signaling cascade of the MAVS pathway ... this finding solidified its place as the elusive cytosolic DNA sensor to complete the cGAS-cGAMP-STING pathway. “It was quite a surprise ...