In addition, several more broadly expressed transcription factors, including members of the STAT family, also have been shown to have key roles in hematopoiesis. In this review, we summarize ...

The signal transducer and activator of transcription (STAT) transcription factors are activated by direct tyrosine phosphorylation in response to cytokines, growth factors and other hormones.

Transcription factors like STAT5 are similar to genetic light switches and capable of turning genes on and off. But previous strategies to target STAT transcription factors have been difficult and ...

Sanofi paid $55 million to partner with the biotech in 2019 and handed over a further $22 million to expand the collaboration ...

pathway comprises four JAK kinases and seven STAT transcription factors. Among the latter, STAT3 is the best-known oncogene and its essential role in normal tissue makes its complete blockage useless ...

This past year marked the 20th anniversary of the discovery of the Janus kinase (JAK)–signal transducer and activator of transcription (STAT ... of secreted factors that belong to different ...

Group B, showed high phosphorylation levels of ERK1/2 and STAT transcription factors and samples significantly partitioned in two clusters of 7 and 5 cases designated C and D. Group C showed elevated ...