Increased understanding of the Skp2 gene and its relation to cellular senescence may lead to the development of novel agents that can suppress tumor development in common types of cancer ...

Recent findings show that Akt — a major kinase that coordinates diverse signalling pathways — phosphorylates Skp2, a subunit of the SCF-Skp2 ubiquitin ligase that targets key cell-cycle ...

【化学合成】 通过亲核取代等反应构建2,3-二芳基吡嗪骨架，重点优化右翼苄基和左翼芳基结构，获得10h等38个衍生物。 【Skp2-Cks1抑制活性】 均相时间分辨荧光（HTRF）检测显示10h的IC 50 较先导 ...

Skp2 mRNA and protein content is cell cycle regulated with highest expression levels at the G1/S transition and early S phase. There is evidence that this regulation occurs at the ...

Pregnancy Outcome of Partners of Male Survivors of Childhood Cancer: A Report From the Childhood Cancer Survivor Study Methods: Clinicopathologic features and immunohistochemical expression of Skp2, ...

Their research focused on Skp2 E3 ligase, a protein that binds to and tags other proteins with molecules called ubiquitins, in this case to activate the Akt kinase. "We discovered a novel function ...

Skp2 is involved in promoting cell cycle regulation, cell proliferation, cell growth and the formation of tumors, and it is overexpressed in a variety of human cancers, according to lead author ...