Dr. Sinclair dosed his mice daily with 22 milligrams of resveratrol for each kilogram of weight to protect them from the diseases of obesity. For an 80 kilogram man that would be 1.7 grams per day.

SIRT1 is an enzyme in the class of molecules called Sirtuins. Significant research shows that activation of sirtuins reduces cellular aging through its interaction with other cellular master switches ...

Franklin H. Epstein, M.D., served the New England Journal of Medicine for more than 20 years. A keen clinician, accomplished researcher, and outstanding teacher, Dr. Epstein was Chair and ...

Due to the difficulty of identifying activators that upregulate more sirtuin enzymes under more physiologically relevant conditions, companies such as Elysium Health (MIT) had largely abandoned ...

A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 15, Issue 23, entitled, "Sirtuin 6 activation rescues the age ...

Figure 1: Effect of polyphenolic STACs on sirtuins. To assay worm feeding rates, worms at the indicated stages were placed on treatment plates (no FUDR) for 4–5 h, then videoed for 1 min ...

To date, sirtuin activation has been pursued pharmaceutically for SIRT1 by allosteric activation and for other sirtuins by nutraceutical supplements that are not drugs. CCM's sirtuin-activating ...

These compounds are also undergoing animal testing in mice for age-related disorders, including infertility, where they have outperformed both NAD+ supplements and existing sirtuin activators.